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著作: [樋浦 明夫]/[中川 弘]/Capsaicin-resistant, nonspecific acetylcholinesterase (NsAchE) reactive nerve fibers in the rat cornea: a quantitative and developmental study (Cited in "Investigative Ophtalmology & Visual Science, 52(5), 2010")/[Okajimas Folia Anatomica Japonica]

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EID
117378
EOID
732709
Map
0
LastModified
2014年5月8日(木) 16:27:04
Operator
樋浦 明夫
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樋浦 明夫
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 樋浦 明夫
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 中川 弘([徳島大学.病院.診療科.小児歯科])
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Capsaicin-resistant, nonspecific acetylcholinesterase (NsAchE) reactive nerve fibers in the rat cornea: a quantitative and developmental study (Cited in "Investigative Ophtalmology & Visual Science, 52(5), 2010")

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(英) Little is known whether capsaicin affects on the nonspecific acetylcholinesterase (NsAchE) positive nerves in the cornea. To examine this point, the density of the corneal nerve fibers stained with NsAchE method was compared with that of control. Capsaicin (50 mg/kg) was injected once into the dorsal skin of rats at 2 day after birth. As controls, a vehicle was similarly injected into animals of the same age. At 5 (n = 3), 17 (n = 4), 45 (n = 4) and 75 (n = 3) days after treatment, the bilateral corneas were excised from capsaicin treated (n = 14) and age-matched control animals (n = 14). The entire subepithelial corneal nerves stained in whole mount preparations were hand traced. Their density was represented as mm/mm2 by converting the total areas of the nerve fibers into the total length of them using computer image analysis system. No significant differences in the nerve fiber density were seen in the control and capsaicin-treated corneas at the survival times examined. Even high doses of neonatal capsaicin injection (total: 150 mg/kg) no NsAchE-reacted corneal nerves showed a significant decrease. However, the time of wiping by instillation of 100 microM capsaicin onto the corneas severely reduced (analgesia to chemical irritant) in the neonatal capsaicin-treated rats (50 mg/kg, n = 13) compared with those of controls (n = 13) at 17, 45 and 75 day survivals. This was closely associated with the decrease of PGP-ir intraepithelial nerve fibers. The corneal nerves reacted with the NsAchE seemed to be capsaicin resistant and have a functional property except the chemical nociception.

キーワード 推奨
  1. (英) Acetylcholinesterase
  2. (英) Animals
  3. (英) Capsaicin
  4. (英) Cornea
  5. (英) Female
  6. (英) Male
  7. (英) Nerve Fibers
  8. (英) Rats
  9. (英) Rats, Wistar
発行所 推奨 慶應義塾大学
誌名 必須 Okajimas Folia Anatomica Japonica(オカジマ・フォリア・アナトミカ・ヤポニカ編集部)
(pISSN: 0030-154X, eISSN: 1881-1736)
ISSN 任意 0030-154X
ISSN: 0030-154X (pISSN: 0030-154X, eISSN: 1881-1736)
Title: Okajimas folia anatomica Japonica
Title(ISO): Okajimas Folia Anat Jpn
Supplier: オカジマ・フォリア・アナトミカ・ヤポニカ編集部
Publisher: Okajimas Folia Anatomica Yaponika Henshubu
 (NLM Catalog  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 81
必須 4
必須 75 84
都市 任意 東京(Tokyo/[日本国])
年月日 必須 2004年 8月 初日
URL 任意 http://ci.nii.ac.jp/naid/80017039070/
DOI 任意
PMID 任意 15615030    (→Scopusで検索)
NAID 任意 80017039070
WOS 任意
Scopus 任意
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指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of 2nd Oral Anatomy, School of Dentistry, University of Tokushima. hiuraaki@dent.tokushima-u.ac.jp

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article