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著作: [山﨑 尚志]/筋型カルニチンパルミトイル転移酵素の発見とその遺伝子構造の解析/[薬学雑誌]

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EID
113846
EOID
711390
Map
0
LastModified
2013年9月11日(水) 16:11:45
Operator
大家 隆弘
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TRUE
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0
Owner
山﨑 尚志
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種別 必須 総説·解説
言語 必須 日本語
招待 推奨 依頼
審査 推奨
カテゴリ 推奨 研究
共著種別 推奨
学究種別 推奨
組織 推奨
  1. 徳島大学.薬学部.製薬化学科.薬品素材学講座(〜2006年3月31日)
著者 必須
  1. 山﨑 尚志([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.薬物治療学])
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Identification of muscle-type carnitine palmitoyltransferase I and characterization of its gene structure

(日) 筋型カルニチンパルミトイル転移酵素の発見とその遺伝子構造の解析

副題 任意
要約 任意

(英) To characterize energy metabolism in brown adipose tissue (BAT), differential screening of a cDNA library of rat BAT with a cDNA probe of rat white adipose tissue was carried out. We isolated one novel cDNA clone encoding a protein of 88.2 kDa consisting of 772 amino acids. The deduced amino acid sequence showed the highest homology (62.6%) with that of rat liver carnitine palmitoyltransferase I (CPTI). The transcript corresponding to this cDNA was abundantly expressed not only in BAT but also in the heart and skeletal muscle. CPTI is a protein necessary for the beta-oxidation of long-chain fatty acids in mammalian mitochondria, and it has been suggested that at least two isoforms, the liver type and muscle (M-CPTI) type, exist. Based on these observations, we concluded that the novel cDNA clone isolated from rat BAT encodes M-CPTI. Isolation and characterization of a genomic DNA clone revealed that the gene for human M-CPTI consists of two 5'-noncoding exons, 18 coding exons, and one 3'-noncoding exon spanning approximately 10 kbp, and a gene encoding choline/ethanolamine kinase-beta (CK/EK-beta) was located about 300 bp upstream from the M-CPTI gene with the same strand direction. Furthermore, we found atypical transcripts containing exons of both CK/EK-beta and M-CPTI genes in humans and rodents. The physiologic role(s) of these transcripts is still unknown. However, it is interesting that such transcripts are produced from two tightly arranged and functionally unrelated genes in mammalian tissues.

キーワード 推奨
  1. (英) Adipose Tissue, Brown
  2. (英) Animals
  3. (英) Carnitine O-Palmitoyltransferase
  4. (英) Exons
  5. (英) Fatty Acids
  6. (英) Gene Library
  7. (英) Genes, Overlapping
  8. (英) Humans
  9. (英) Liver
  10. (英) Muscle, Skeletal
  11. (英) Myocardium
  12. (英) Oxidation-Reduction
  13. (英) RNA, Messenger
  14. (英) Rats
  15. (英) Sequence Homology, Amino Acid
発行所 推奨
誌名 必須 薬学雑誌([日本薬学会])
(pISSN: 0031-6903, eISSN: 1347-5231)
ISSN 任意 0031-6903
ISSN: 0031-6903 (pISSN: 0031-6903, eISSN: 1347-5231)
Title: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
Title(ISO): Yakugaku Zasshi
Supplier: 公益社団法人日本薬学会
Publisher: Pharmaceutical Society of Japan
 (NLM Catalog  (Webcat Plus  (Webcat Plus  (医中誌Web  (J-STAGE  (J-STAGE  (J-STAGE  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 124
必須 12
必須 893 908
都市 任意
年月日 必須 2004年 12月 初日
URL 任意
DOI 任意 10.1248/yakushi.124.893    (→Scopusで検索)
PMID 任意 15577262    (→Scopusで検索)
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指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Faculty of Pharmaceutical Sciences, University of Tokushima, Tokushima 770-8505, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: English Abstract

  3. (英) Article.PublicationTypeList.PublicationType: Journal Article

  4. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

  5. (英) Article.PublicationTypeList.PublicationType: Review

  6. (英) NumberOfReferences: 50