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著作: [漆原 真樹]/[香美 祥二]/Kuhara Takeshi/[玉置 俊晃]/[黒田 𣳾弘]/Glomerular distribution and gelatinolytic activity of natrix metalloproteinases in human glomerulonephritis./[Nephrology, Dialysis, Transplantation]

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EID
113740
EOID
717023
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0
LastModified
2013年11月25日(月) 16:03:35
Operator
三木 ちひろ
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Owner
玉置 俊晃
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
  1. 徳島大学.大学院ヘルスバイオサイエンス研究部.神経情報医学部門.病態情報医学講座(2004年4月1日〜)
著者 必須
  1. 漆原 真樹([徳島大学.病院.診療科.小児·周産·女性科.小児科])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. 香美 祥二([徳島大学.病院])
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Kuhara Takeshi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. 玉置 俊晃
    役割 任意
    貢献度 任意
    学籍番号 推奨
  5. 黒田 𣳾弘
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Glomerular distribution and gelatinolytic activity of natrix metalloproteinases in human glomerulonephritis.

副題 任意
要約 任意

(英) Matrix metalloproteinases (MMPs) have been implicated in the development of glomerular injury in rat experimental glomerulonephritis (GN). However, the significance of MMPs in human GN remains obscure. In order to evaluate the role of MMPs in human GN, we examined the glomerular distribution and gelatinolytic activities of MMP-2 and MMP-9 in human GN. We performed immunohistochemistry with polyclonal anti-MMP-2 and MMP-9 antibodies, and analysed gelatin zymograms of five isolated glomeruli from various types of human renal disease. The renal specimens investigated were from normal kidneys (n=5), IgA nephritis (n=20), Henoch-Schönlein nephritis (n=4), non-IgA mesangial proliferative GN (n=9), lupus nephritis (n=6), acute poststreptococcal GN (APSGN) (n=4) and diabetic nephropathy (DN) (n=4). MMP-2 immunoreactivity was not detected in normal controls or in any type of GN. MMP-9 staining, which was almost negative in normal glomeruli, was increased mainly in the mesangial region and corresponded to the level of glomerular cell proliferative changes in mesangial proliferative GN (IgA nephritis, Henoch-Schönlein nephritis, non-IgA mesangial proliferative GN and lupus nephritis). Positive but weak staining for MMP-9 was observed in mesangial areas in DN. In addition, double immunostaining showed that MMP-9 is colocalized in scattered neutrophils within diseased glomeruli in APSGN. MMP-9 gelatinolytic activity in five normal glomeruli was weakly detected. Consistent with the levels of immunostaining, MMP-9 glomerular activity was dramatically increased in nephritic glomeruli with IgA nephritis, lupus nephritis and DN. The gelatinolytic activity of MMP-2 was occasionally detectable in nephritic glomeruli. These results strongly suggest that MMP-9 plays an important role in abnormal mesangial proliferative changes in human GN.

キーワード 推奨
  1. 細胞分裂(cell division)
  2. (英) Gelatinases
  3. (英) Glomerulonephritis
  4. (英) Humans
  5. 免疫組織化学(immunohistochemistry)
  6. (英) Kidney Glomerulus
  7. (英) Matrix Metalloproteinase 2
  8. (英) Matrix Metalloproteinase 9
  9. (英) Matrix Metalloproteinases
  10. (英) Reference Values
発行所 推奨
誌名 必須 Nephrology, Dialysis, Transplantation([Oxford University Press])
(pISSN: 0931-0509, eISSN: 1460-2385)
ISSN 任意 0931-0509
ISSN: 0931-0509 (pISSN: 0931-0509, eISSN: 1460-2385)
Title: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Title(ISO): Nephrol Dial Transplant
Supplier: Oxford University Press
Publisher: Oxford University Press
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 17
必須 7
必須 1189 1196
都市 任意
年月日 必須 2002年 7月 初日
URL 任意
DOI 任意 10.1093/ndt/17.7.1189    (→Scopusで検索)
PMID 任意 12105240    (→Scopusで検索)
NAID 任意
WOS 任意 000176943000008
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
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  1. (英) Article.Affiliation: Department of Pediatrics, School of Medicine, University of Tokushima, Tokushima, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't