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著作: Kurabuchi, Shingo/Gresik, W Edward/[細井 和雄]/Additive and/or synergistic action (downregulation) of androgens and thyroid hormones on the cellular distribution and Localization of a true tissue kallikrein, mK1, in the mouse submandibular gland/[The Journal of Histochemistry and Cytochemistry]

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EID
113725
EOID
876671
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2017年12月2日(土) 21:15:05
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大家 隆弘
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細井 和雄
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨 Peer Review
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. (英) Kurabuchi, Shingo
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Gresik, W Edward
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. 細井 和雄
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Additive and/or synergistic action (downregulation) of androgens and thyroid hormones on the cellular distribution and Localization of a true tissue kallikrein, mK1, in the mouse submandibular gland

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要約 任意

(英) We investigated the effects of 5alpha-dihydrotestosterone (DHT), 3,5,3'-triiodo-l-thyronine (T(3)), and dexamethasone (Dex) on the expression of mK1 in the granular convoluted tubule (GCT) cells of the submandibular gland (SMG) of hypophysectomized (Hypox) male mice by indirect enzyme-labeled antibody and immunogold antibody methods for light and electron microscopy. Hypox resulted in considerable atrophy of the GCT cells, which were always immunoreactive for mK1, and the cells were characterized by apical small dense secretory granules labeled with gold particles suggesting the presence of mK1, small Golgi apparatus, sparse rough endoplasmic reticulum (RER), and developed basal infoldings. Each of the hormones, DHT, T(3), and Dex, enhanced the GCT phenotype to various degrees in Hypox male mice. Both DHT alone and T(3) alone moderately inhibited mK1 synthesis by increasing the number of mK1-immunonegative GCT cells in Hypox males, but Dex alone had no inhibitory effect on mK1 synthesis. A significant trophic effect on GCT cells was induced by combined injection of DHT and T(3) or of all three hormones, and was reflected in the appearance of abundant large secretory granules, well-developed Golgi apparatus and RER, and reduced basal infoldings. Only a few such GCT cells were immunopositive for mK1, and the pattern of immunopositive and immunonegative cells very closely resembled the mosaic pattern seen in normal male GCTs. These findings suggested that the sexual dimorphism of mK1 expression and the morphological appearance of GCT cells can be induced by treatment with two hormones, DHT and T(3), but not by either of them alone. T(3) appears to have a permissive effect on committed GCT cells that results in downregulation of mK1 expression in these cells.

キーワード 推奨
  1. (英) Androgens
  2. (英) Animals
  3. (英) Dexamethasone
  4. (英) Dihydrotestosterone
  5. (英) Down-Regulation
  6. (英) Female
  7. (英) Immunohistochemistry
  8. (英) Male
  9. (英) Mice
  10. (英) Mice, Inbred ICR
  11. (英) Microscopy, Electron
  12. (英) Submandibular Gland
  13. (英) Thyroid Hormones
  14. (英) Tissue Kallikreins
  15. (英) Triiodothyronine
発行所 推奨
誌名 必須 The Journal of Histochemistry and Cytochemistry(The Histochemical Society)
(pISSN: 0022-1554, eISSN: 1551-5044)
ISSN 任意 0022-1554
ISSN: 0022-1554 (pISSN: 0022-1554, eISSN: 1551-5044)
Title: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Title(ISO): J Histochem Cytochem
Publisher: Histochemical Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
必須 52
必須 11
必須 1437 1446
都市 任意
年月日 必須 2004年 11月 初日
URL 任意
DOI 任意 10.1369/jhc.4A6333.2004    (→Scopusで検索)
PMID 任意 15505338    (→Scopusで検索)
NAID 任意
WOS 任意 000225273700005
Scopus 任意
評価値 任意
被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Dept. of Histology, Nippon Dental University School of Dentistry at Tokyo, Fujimi 1-9-20, Chiyoda-ku, Tokyo 102-8159, Japan. kurabuchi@tokyo.ndu.ac.jp

  2. (英) Article.PublicationTypeList.PublicationType: Journal Article

  3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

  4. (英) Article.PublicationTypeList.PublicationType: Research Support, U.S. Gov't, P.H.S.