著作: Sakai T/Agui T/[松本 耕三]/Abnormal CD45RC expression and elevated CD45 protein tyrosine phosphatase activity in LEC rat peripheral CD4+ T Cells./[European Journal of Immunology]
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| 種別 | 必須 | 学術論文(審査論文) | |||||||||||||||||||||||||||
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| 言語 | 必須 | 英語 | |||||||||||||||||||||||||||
| 招待 | 推奨 | ||||||||||||||||||||||||||||
| 審査 | 推奨 | Peer Review | |||||||||||||||||||||||||||
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| 題名 | 必須 |
(英) Abnormal CD45RC expression and elevated CD45 protein tyrosine phosphatase activity in LEC rat peripheral CD4+ T Cells. |
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| 副題 | 任意 | ||||||||||||||||||||||||||||
| 要約 | 任意 |
(英) LEC rats are known to show a maturational arrest in the development of CD4+8+ to CD4+8- cells in the thymus. Despite the blockade of maturation of CD4+8-thymocytes, CD4+ T cells were observed in peripheral lymphoid organs, and these cells exhibit a defect in interleukin-2 (IL-2) production upon concanavalin A (Con A) stimulation. Although peripheral CD4+ cells in normal rat highly expressed CD45RC (CD45RChigh), the level of CD45RC expression was low (CD45RClow) in LEC rat peripheral CD4+ cells. However, CD4+ cells from both strains highly expressed CD45 when those cells were stained by pan-CD45 mAb, suggesting that LEC rat CD4+ cells are deficient in expression of the CD45RC isoform, but not of CD45 molecules. When backcross rats from (F344 x LEC)F1 x LEC were examined, the phenotype for CD45 expression pattern in CD4+ cells was clearly correlated with IL-2 production level in response to Con A stimulation. Thus, CD45RClow cells exhibit a defect in IL-2 production, while CD45RChigh cells show normal IL-2 production. Protein tyrosine phosphatase (PTPase) activity in the membrane fraction of LEC rat CD4+ cells was threefold higher than that of normal rat CD4+ cells. Con A stimulation led to an increase in tyrosine phosphorylation levels, especially 100- and 40-kDa proteins, in normal rat CD4+ cells. In LEC rat CD4+ cells, however, the level of tyrosine phosphorylation in those proteins were very low. These results suggest that an elevated CD45 PTPase activity is responsive for a defect in IL-2 production in LEC rat peripheral CD4+ T cells. |
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| 発行所 | 推奨 | ||||||||||||||||||||||||||||
| 誌名 | 必須 |
European Journal of Immunology(European Federation of Immunological Societies)
(pISSN: 0014-2980, eISSN: 1521-4141)
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| 巻 | 必須 | 25 | |||||||||||||||||||||||||||
| 号 | 必須 | 5 | |||||||||||||||||||||||||||
| 頁 | 必須 | 1399 1404 | |||||||||||||||||||||||||||
| 都市 | 任意 | ||||||||||||||||||||||||||||
| 年月日 | 必須 | 1995年 5月 初日 | |||||||||||||||||||||||||||
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| DOI | 任意 | 10.1002/eji.1830250539 (→Scopusで検索) | |||||||||||||||||||||||||||
| PMID | 任意 | 7774643 (→Scopusで検索) | |||||||||||||||||||||||||||
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| 指導教員 | 推奨 | ||||||||||||||||||||||||||||
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