113512: Ogino T/Moralejo DH/Zhu M/Toide K/Wei S/Wei K/Yamada T/Mizuno A/[松本耕三]/Identification of possible quantitative trait loci responsible for hyperglycemia after 70% pancreatectomy using a spontaneously diabetogenic rat./[Genetical Research]

著作: Ogino T/Moralejo DH/Zhu M/Toide K/Wei S/Wei K/Yamada T/Mizuno A/[松本耕三]/Identification of possible quantitative trait loci responsible for hyperglycemia after 70% pancreatectomy using a spontaneously diabetogenic rat./[Genetical Research]

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種別

必須

学術論文(審査論文)

言語

必須

英語

招待

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審査

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Peer Review

カテゴリ

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共著種別

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学究種別

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組織

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徳島大学.医学部.附属動物実験施設(->組織[徳島大学.大学院ヘルスバイオサイエンス研究部.総合研究支援センター.動物資源研究部門])

著者

必須

(英) Ogino T

役割任意

貢献度任意

学籍番号推奨
(英) Moralejo DH

役割任意

貢献度任意

学籍番号推奨
(英) Zhu M

役割任意

貢献度任意

学籍番号推奨
(英) Toide K

役割任意

貢献度任意

学籍番号推奨
(英) Wei S

役割任意

貢献度任意

学籍番号推奨
(英) Wei K

役割任意

貢献度任意

学籍番号推奨
(英) Yamada T

役割任意

貢献度任意

学籍番号推奨
(英) Mizuno A

役割任意

貢献度任意

学籍番号推奨
松本耕三

役割任意

貢献度任意

学籍番号推奨

題名

必須

(英) Identification of possible quantitative trait loci responsible for hyperglycemia after 70% pancreatectomy using a spontaneously diabetogenic rat.

副題

任意

要約

任意

(英) The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is an animal model for obese-type non-insulin-dependent diabetes mellitus (NIDDM) in humans. The OLETF rat exhibits sustained hyperglycaemia after partial pancreatectomy, while the normal control rat does not. This difference is thought to be genetically determined and to be caused by impairment of beta-cell regrowth, a possible event involved in the pathogenesis of NIDDM. Our investigation was designed to identify quantitative trait loci (QTL) responsible for post-pancreatectomy hyperglycaemia by performing a genome-wide scan in an F2 intercross obtained by mating the OLETF and Fischer-344 (F344) rats. We have identified three possible QTL on rat chromosomes (Chrs) 3, 14 and 19 that account for a total of approximately 75% of the genetic variance in the F2. For the QTL on Chr 14, the OLETF allele corresponds with increased glucose levels, as expected. Surprisingly, for the QTL on Chr 19, the F344 allele corresponds with increased glucose levels. The Chr 3 QTL exhibits heterosis, heterozygotes showing significantly higher glucose levels than OLETF or F344 homozygotes. We also found evidence for interaction (epistasis) between the QTL on Chrs 14 and 19.

キーワード

推奨

(英) Animals
(英) Chromosome Mapping
(英) Diabetes Mellitus, Type 2
(英) Female
(英) Humans
(英) Hyperglycemia
(英) Male
(英) Pancreatectomy
(英) Quantitative Trait, Heritable
(英) Rats
(英) Rats, Inbred F344
(英) Rats, Mutant Strains

発行所

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誌名

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Genetical Research([Cambridge University Press])

(pISSN: 0016-6723, eISSN: 1469-5073)

ISSN	任意	0016-6723 ISSN: 0016-6723 (pISSN: 0016-6723, eISSN: 1469-5073) Title: Genetics research Title(ISO): Genet Res (Camb) Publisher: Cambridge University Press (NLM Catalog) (Scopus) (CrossRef) (Scopus information is found. [need login])

巻

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号

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頁

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29 36

都市

任意

年月日

必須

1999年 2月初日

URL

任意

DOI

任意

10.1017/S0016672398003644 (→Scopusで検索)

PMID

任意

10218444 (→Scopusで検索)

CRID

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WOS

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Scopus

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評価値

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被引用数

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指導教員

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備考

任意

(英) Article.Affiliation: Institute for Animal Experimentation, University of Tokushima School of Medicine, Japan.
(英) Article.PublicationTypeList.PublicationType: Journal Article
(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

徳島大学教育・研究者情報データベース(EDB)

Education and Research Database (EDB), Tokushima University

著作: Ogino T/Moralejo DH/Zhu M/Toide K/Wei S/Wei K/Yamada T/Mizuno A/[松本耕三]/Identification of possible quantitative trait loci responsible for hyperglycemia after 70% pancreatectomy using a spontaneously diabetogenic rat./[Genetical Research]

著作: Ogino T/Moralejo DH/Zhu M/Toide K/Wei S/Wei K/Yamada T/Mizuno A/[松本 耕三]/Identification of possible quantitative trait loci responsible for hyperglycemia after 70% pancreatectomy using a spontaneously diabetogenic rat./[Genetical Research]

著作: Ogino T/Moralejo DH/Zhu M/Toide K/Wei S/Wei K/Yamada T/Mizuno A/[松本耕三]/Identification of possible quantitative trait loci responsible for hyperglycemia after 70% pancreatectomy using a spontaneously diabetogenic rat./[Genetical Research]