徳島大学 教育・研究者情報データベース(EDB)

1. (英) Hayashi Yuki

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2. 石丸 直澄

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3. 新垣 理恵子

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4. 九十九 伸一([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])

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5. 福井 仁美([徳島大学.大学院ヘルスバイオサイエンス研究部.医療創生科学部門.分子口腔医学講座.口腔分子病態学])

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6. 岸原 健二

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7. 塩田 洋

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8. 安友 康二([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])

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9. 林 良夫

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(英) Effective Treatment of a Mouse Model of Sjogren's Syndrome With Eyedrop Administrasiton of Anti-CD4 Monoclonal Antibody

(英) To determine whether eyedrop administration of an anti-CD4 monoclonal antibody (mAb) is effective in the treatment of Sjögren's syndrome (SS) using a mouse model of the disease. The anti-CD4 mAb was administered daily into the eyes of mice with SS from ages 4 to 8 weeks or ages 10 to 12 weeks. During treatment, tear volume was monitored and after final treatment, histologic features of the lacrimal and salivary glands, the phenotypes and function of T cells, and serum titers of anti-alpha-fodrin antibody were examined. Eyedrop administration of anti-CD4 mAb before the onset of SS prevented the autoimmune pathology seen in the lacrimal glands but not that in the salivary glands. Furthermore, eyedrop administration of anti-CD4 mAb after the development of SS inhibited mononuclear cell infiltration and the destruction of parenchyma only in the lacrimal glands. Eyedrop administration of anti-CD4 mAb suppressed the local activation of CD4+ T cells rather than deleting CD4+ T cells, which reduced the expansion of pathologic CD4+ T cells against alpha-fodrin. These results demonstrate the remarkable efficacy of anti-CD4 mAb eyedrops in the treatment of SS eye symptoms, which illustrates a new antibody-based therapeutic strategy for patients with eye problems caused by SS as well as other diseases.

1. (英) Administration, Topical
2. (英) Animals
3. (英) Antibodies, Monoclonal
4. (英) Antigens, CD4
5. (英) CD4-Positive T-Lymphocytes
6. (英) Disease Progression
7. (英) Dry Eye Syndromes
8. (英) Female
9. (英) Lacrimal Apparatus
10. (英) Lymphocyte Activation
11. (英) Mice
12. (英) Models, Animal
13. (英) Ophthalmic Solutions
14. 唾液腺(salivary glands/->キーワード[唾液腺])
15. シェーグレン症候群(Sjögren's syndrome)
16. (英) Treatment Outcome

1. (英) Article.Affiliation: The University of Tokushima School of Medicine, Tokushima, Japan.

2. (英) Article.PublicationTypeList.PublicationType: Journal Article

3. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't