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著作: [石川 康子]/Amano Ichiro/Eguchi Takafumi/Ishida Hajime/Mechanism of isoproterenol-induced heterologous desensitization of mucin secretion from rat submandibular glands: Regulation of phosphorylation of Gi proteins controls the cell response to the subsequent stimulation./[Biochimica et Biophysica Acta (BBA) - Molecular Cell Research]

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EID
104110
EOID
711537
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0
LastModified
2013年9月11日(水) 20:44:30
Operator
大家 隆弘
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石川 康子
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種別 必須 学術論文(審査論文)
言語 必須 英語
招待 推奨
審査 推奨
カテゴリ 推奨
共著種別 推奨
学究種別 推奨
組織 推奨
著者 必須
  1. 石川 康子
    役割 任意
    貢献度 任意
    学籍番号 推奨
  2. (英) Amano Ichiro
    役割 任意
    貢献度 任意
    学籍番号 推奨
  3. (英) Eguchi Takafumi
    役割 任意
    貢献度 任意
    学籍番号 推奨
  4. (英) Ishida Hajime
    役割 任意
    貢献度 任意
    学籍番号 推奨
題名 必須

(英) Mechanism of isoproterenol-induced heterologous desensitization of mucin secretion from rat submandibular glands: Regulation of phosphorylation of Gi proteins controls the cell response to the subsequent stimulation.

副題 任意
要約 任意

(英) Short-term treatment of rat submandibular tissues with 10 microM isoproterenol (IPR) resulted in reduction of mucin secretion in response to the agonist during further incubation, and in increases in EC50 values. This IPR-induced reduction of secretion was coupled with selective decreases in the number of beta-adrenoceptors in the tissues and in their affinity for agonists, as assessed by measurement of the specific binding of [3H]dihydroalprenolol. Treatment of the tissues with IPR caused a 30% decrease in IPR-stimulated adenylate cyclase activity and a 25% increase in the GTP binding capacity of inhibitory G proteins (Gi proteins). This IPR treatment triggered a 60% increase in the ability of pertussis toxin (IAP) to catalyze ADP-ribosylation of Gi proteins in the tissue membranes. Enhanced function of stimulatory G proteins (Gs proteins) was observed only during the first incubation of the tissues with IPR. The IAP-catalyzed ADP-ribosylation of Gi proteins in tissues treated with IPR was decreased by prior treatment with cyclic AMP dependent protein kinase, but was increased markedly by prior treatment with alkaline phosphatase. Neither IPR-induced desensitization of protein secretion nor increase in the IAP-catalyzed ADP-ribosylation of Gi proteins was observed in the tissues pretreated with 0.25 microM okadaic acid. These findings suggest that the regulation of Gi protein phosphorylation plays an important role in the IPR-induced heterologous desensitization of mucin secretion from rat submandibular glands.

キーワード 推奨
  1. 顎口腔機能(stomatognathic function)
  2. 情報伝達機構(signal transduction)
  3. 神経伝達物質(neurotransmitter)
  4. (英) Grug receptors
  5. (英) GTP binding protein
発行所 推奨
誌名 必須 Biochimica et Biophysica Acta (BBA) - Molecular Cell Research([Elsevier Science])
(pISSN: 0167-4889)
ISSN 任意 0167-4889
ISSN: 0167-4889 (pISSN: 0167-4889, eISSN: 1879-2596)
Title: Biochimica et biophysica acta. Molecular cell research
Title(ISO): Biochim Biophys Acta Mol Cell Res
Publisher: Elsevier BV
 (NLM Catalog  (CrossRef (Scopus information is found. [need login])
必須 1265
必須 2-3
必須 173 180
都市 任意
年月日 必須 1995年 3月 16日
URL 任意 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7696346&dopt=Abstract
DOI 任意 10.1016/0167-4889(94)00216-2    (→Scopusで検索)
PMID 任意 7696346    (→Scopusで検索)
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被引用数 任意
指導教員 推奨
備考 任意
  1. (英) Article.Affiliation: Department of Pharmacology, Tokushima University School of Dentistry, Japan.

  2. (英) Article.PublicationTypeList.PublicationType: In Vitro

  3. (英) Article.PublicationTypeList.PublicationType: Journal Article

  4. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't