101328: [前川洋一]/Tsukumo Shin-ichi/Chiba Shigeru/Hirai Hisamaru/Hayashi Yuki/Okada Hiroko/Kishihara Kenji/[安友康二]/Deltal-Notch3 interactious bias the functional differentiation of activated CD4+ T-Cells/[Immunity]

著作: [前川洋一]/Tsukumo Shin-ichi/Chiba Shigeru/Hirai Hisamaru/Hayashi Yuki/Okada Hiroko/Kishihara Kenji/[安友康二]/Deltal-Notch3 interactious bias the functional differentiation of activated CD4+ T-Cells/[Immunity]

ヘルプを読む

「著作」（著作（著書，論文，レター，国際会議など））は，研究業績にかかる著作（著書，論文，レター，国際会議など）を登録するテーブルです． (この情報が属するテーブルの詳細な定義を見る)

項目名の部分にマウスカーソルを置いて少し待つと，項目の簡単な説明がツールチップ表示されます．

この情報をEDB閲覧画面で開く

EID: 101328
EOID: 669445
Map: 0
LastModified: 2012年11月5日(月) 15:59:56
Operator: 三木ちひろ
Avail: TRUE
Censor: 0
Owner: 安友康二
Read: 継承
Write: 継承
Delete: 継承

種別

必須

学術論文(審査論文)

言語

必須

英語

招待

推奨

審査

推奨

Peer Review

カテゴリ

推奨

共著種別

推奨

学究種別

推奨

組織

推奨

著者

必須

前川洋一

役割任意

貢献度任意

学籍番号推奨
(英) Tsukumo Shin-ichi

役割任意

貢献度任意

学籍番号推奨
(英) Chiba Shigeru

役割任意

貢献度任意

学籍番号推奨
(英) Hirai Hisamaru

役割任意

貢献度任意

学籍番号推奨
(英) Hayashi Yuki

役割任意

貢献度任意

学籍番号推奨
(英) Okada Hiroko

役割任意

貢献度任意

学籍番号推奨
(英) Kishihara Kenji

役割任意

貢献度任意

学籍番号推奨
安友康二([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])

役割任意

貢献度任意

学籍番号推奨

題名

必須

(英) Deltal-Notch3 interactious bias the functional differentiation of activated CD4+ T-Cells

副題

任意

要約

任意

(英) Following activation by antigen, naive CD4+ T helper precursor cells execute distinct genetic programs that result in their differentiation toward the type 1 or type 2 helper T cell (Th1 or Th2) phenotype. Although the differentiation and function of these Th subsets has been well studied, little is known about the contribution to these differentiation events of cell surface receptors other than those for soluble cytokines, such as IL-12 or IL-4. Here, we provide direct evidence that the Delta1 interaction with Notch3 on CD4+ T cells transduces signals, promoting development toward the Th1 phenotype. The positive role of Notch signaling in effector cell differentiation was dose dependent, with high levels of stimulation resulting in reduced T cell activation. Our data revealed a clear contribution of Notch pathways to Th1 versus Th2 fate decisions, while also providing insight into another mechanism for inhibition of CD4+ T cell activation.

キーワード

推奨

(英) Animals
(英) CD4-Positive T-Lymphocytes
細胞分化(cell differentiation)
(英) Interferon-gamma
(英) Intracellular Signaling Peptides and Proteins
(英) Leishmania major
(英) Leishmaniasis, Cutaneous
(英) Membrane Proteins
(英) Mice
(英) Proto-Oncogene Proteins
(英) Receptors, Cell Surface
(英) Receptors, Notch
(英) T-Box Domain Proteins
(英) Transcription Factors

発行所

推奨

誌名

必須

Immunity(Cell Press)

(pISSN: 1074-7613, eISSN: 1097-4180)

ISSN	任意	1074-7613 ISSN: 1074-7613 (pISSN: 1074-7613, eISSN: 1097-4180) Title: Immunity Title(ISO): Immunity Publisher: Cell Press (NLM Catalog) (Scopus) (CrossRef) (Scopus information is found. [need login])

巻

必須

号

必須

頁

必須

549 559

都市

任意

年月日

必須

2003年 10月初日

URL

任意

DOI

任意

10.1016/S1074-7613(03)00270-X (→Scopusで検索)

PMID

任意

14563319 (→Scopusで検索)

CRID

任意

WOS

任意

Scopus

任意

評価値

任意

被引用数

任意

指導教員

推奨

備考

任意

(英) Article.Affiliation: Department of Immunology & Parasitology, School of Medicine, The University of Tokushima, Tokushima 770-8503, Japan.
(英) Article.PublicationTypeList.PublicationType: Journal Article
(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't

徳島大学教育・研究者情報データベース(EDB)

Education and Research Database (EDB), Tokushima University

著作: [前川洋一]/Tsukumo Shin-ichi/Chiba Shigeru/Hirai Hisamaru/Hayashi Yuki/Okada Hiroko/Kishihara Kenji/[安友康二]/Deltal-Notch3 interactious bias the functional differentiation of activated CD4+ T-Cells/[Immunity]

著作: [前川 洋一]/Tsukumo Shin-ichi/Chiba Shigeru/Hirai Hisamaru/Hayashi Yuki/Okada Hiroko/Kishihara Kenji/[安友 康二]/Deltal-Notch3 interactious bias the functional differentiation of activated CD4+ T-Cells/[Immunity]

著作: [前川洋一]/Tsukumo Shin-ichi/Chiba Shigeru/Hirai Hisamaru/Hayashi Yuki/Okada Hiroko/Kishihara Kenji/[安友康二]/Deltal-Notch3 interactious bias the functional differentiation of activated CD4+ T-Cells/[Immunity]