徳島大学 教育・研究者情報データベース(EDB)

1. 徳島大学.医学部.附属動物実験施設(->組織[徳島大学.大学院ヘルスバイオサイエンス研究部.総合研究支援センター.動物資源研究部門])

1. (英) Ogino Tomoe

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2. (英) Moralejo H. Daniel

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3. 小瀬 博之

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4. (英) Yamada Takahisa

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5. 松本 耕三

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(英) Serum leptin concentration is linked to chromosome 2 and 6 in the OLETF rat, animal model of type 2 diabetes with mild obesity.

(英) Leptin is produced by adipose tissue and acts as a feedback signal to the hypothalamus controlling energy homeostasis, by reducing food consumption and increasing energy expenditure. Because serum leptin levels are highly correlated with body fat mass, they can be used as an index to predict obesity-related diseases. However, the identity of genetic factors that influence the obesity and the obesity-related metabolic disorders remains largely unknown. In this study, we performed a whole-genome scan search, using 382 F2 intercross progeny between the Otsuka Long-Evans Tokushima Fatty (OLETF) rat, an animal model for obese type 2 diabetes in human, and F344 rat, in order to identify loci responsible for the regulation of leptin and other obesity-related plasma substances. We have identified two quantitative trait loci (QTLs) contributing to serum leptin levels. These two loci, designated Olep1 [Chromosome (Chr) 2] and Olep2 (Chr 6), were homologous to those of human genome regions containing several potential candidate genes for obesity. These are fatty acid-binding protein 2 (FABP2), FABP4, and FABP5 for Olep1, and proopiomelanocortin (POMC) and glucose regulatory protein (GCKR) for Olep2.

1. (英) Adaptor Proteins, Signal Transducing
2. (英) Animals
3. (英) Carrier Proteins
4. (英) Chromosome Mapping
5. (英) Chromosomes, Mammalian
6. (英) Crosses, Genetic
7. (英) Diabetes Mellitus, Type 2
8. (英) Disease Models, Animal
9. (英) Enzyme-Linked Immunosorbent Assay
10. (英) Fatty Acid-Binding Proteins
11. (英) Humans
12. (英) Leptin
13. (英) Lod Score
14. (英) Microsatellite Repeats
15. (英) Obesity
16. (英) Pro-Opiomelanocortin
17. (英) Quantitative Trait Loci
18. (英) Rats
19. (英) Rats, Inbred F344
20. (英) Rats, Inbred OLETF
21. (英) Synteny

1. (英) Article.Affiliation: Institute for Animal Experimentation, University of Tokushima School of Medicine, Kuramoto 3, Tokushima 770-8503, Japan.

2. (英) Article.PublicationTypeList.PublicationType: Comparative Study

3. (英) Article.PublicationTypeList.PublicationType: Journal Article

4. (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't